phenobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers may possibly improve the metabolism of ifosfamide to its Lively alkylating metabolites.May well cause CNS despair, leading to Actual physical and mental impairment; warning client about performing jobs th